6-Oxo and Testosterone: A Killer Duet Or Just A Hype?

The supplement world is full of hard-to-spell names, pseudo-scientific jargon and lots of doubt. However, there’s one thing most gym-goers agree on. Low testosterone (T) levels are linked to muscle catabolism (breakdown). But, here’s the mistake most athletes and bodybuilders make. It’s not just testosterone that has a say in your muscle anabolism; there’s also estrogen.  Ergopharm 6 oxo was the latest supplement that was taken off the shelf.

While most have associated this hormone with women, estrogen is also part of the male body. However, high quantities of the hormone can spell trouble for the male body, starting with low testosterone and muscle catabolism.

That’s why athletes and bodybuilders resort to testosterone boosters or aromatase inhibitors to jumpstart T production. 6 oxo pct is one of the latest T boosters to hit the shelves with great success. But, is it worth your attention?

What is 6 Oxo?

Also known as androstenedione or “suicidal inhibitor,” 6 oxo is a nutritional supplement designed to inhibit aromatase activity in men. Aromatase is the enzyme responsible for producing estrogen. So, 6 Oxo boosts testosterone levels in men by serving as an excellent estrogen blocker.

Most people in the supplement industry refer to 6 oxo as a natural testosterone booster. However, this supplement ingredient is far from natural. In fact, the World Anti-Doping Agency (WADA) has banned 6-Oxo as a masking agent. After all, this substance is really a prohormone rather than an actual hormone and can be detected in urine. So, no natural elements here.

6 oxo And Testosterone

Aromatase is an enzyme which catalyzes the conversion of androgens such as testosterone and DHT into estrogen through a process known as aromatization. While this process is natural and your hormonal balance depends on it, things get out of hand when aromatase converts more androgens than it should, leading to high estrogen levels in men.

Meanwhile, it irreversibly binds to the aromatase enzyme and results in a decrease in estradiol production thanks to its complex and aromatase-hostile molecular structure. So, in a way, 6 oxo permanently deactivates the estrogen-friendly effect of aromatase.

But, what does this mean for your T levels? To begin with, fewer androgens (testosterone and DHL) are converted into estrogen. In its turn, low estrogen results in increased release of luteinizing hormone (LH) which triggers testosterone production. At the same time, low estrogen levels suppress SHBG (Sex Hormone-Binding Globulin), and this amplifies testosterone synthesis even more.

So, the study published in the Journal of the International Society of Sports Nutrition was right. Six oxo successfully balances testosterone/estrogen ratio in men by increasing free testosterone and DHT (up to 90%) in a variety of hormonal pathways.

Room for Doubt

Even though the previous study claims that testosterone levels skyrocket after the consumption of 6 oxo, there’s still room for doubt. How come? As conflicting as it sounds, the estrogen concentration of the participants didn’t actually decrease during this study. That leaves us wondering whether this substance binds to aromatase permanently or the body produces more to make up for the missing estrogen.

The “Natural” Factor

While research leaves little room for doubt, most people in the fitness community believe that the clock is ticking for 6 oxo. Why? First of all, six oxo doesn’t occur naturally. In fact, it’s synthesized by people in lab coats for a company called ErgoPharm. The mastermind behind this estrogen blocker is Patrick Arnold, an acclaimed chemist. Also, remember that this supplement is a prohormone and not an actual hormone. So, no rocket science here. This supplement is NOT natural.

Recommended Dosage

Following the findings of a recent study, the recommended dosage for the supplement ranges between 300-600 mg a day for eight weeks (maximum). If you stick to these guidelines, there’s no need to worry about potential side effects.

Potential Side Effects of 6-Oxo

The truth is that consuming an artificial substance which suppresses the function of natural reactions in the body doesn’t seem like the safest choice you could make. So, what are the side effects of 6-Oxo?

1. Low Bone Mineral Density

According to one study, men with low estrogen levels are more likely to demonstrate early signs of low bone mineral density. While not life-threatening, this is bad news for your health. However, you’re only at risk if you take 6-oxo supplement for more than eight weeks at a time.

2. Benign Prostatic Hyperplasia

One study proves that there’s a strong connection between increased androgen levels and benign prostatic hyperplasia. But, doesn’t this supplement increase androgens dramatically? Does that mean that those who take the estrogen blocker are in danger? Practically, no. Prolonged use of the supplement results in such side effects. So, make sure to take some time off 6-Oxo after eight weeks.

3. Sexual Function

While testosterone is essential for regulating libido, spermatogenesis and erectile function in men, estradiol, the predominant form of estrogen, is just as important. That’s why low estrogen levels for a prolonged amount of time may result in a variety of sexually-related issues. From low libido to erectile dysfunction, there are a lot of ways in which permanently low estrogen levels can affect a man’s sexual life.

The Takeaway

So, does 6-oxo do the trick? Based on studies so far, yes. This aromatase inhibitor can actually increase testosterone levels by blocking the production of estrogen. However, the fact that it’s not a naturally occurring substance is a bit alarming. Let’s not also forget that it’s on WADA’s “black list.” Wondering where to buy oxo?  Check below to buy 6 oxo supplement

So, should you give it a shot? That’s totally up to you. If you’re okay with taking designer prohormones, then we don’t see a reason why you shouldn’t take 6 oxo for a spin. However, if you prefer natural ingredients, then this aromatase inhibitor is the last thing you should try.  You may want to check out our article on other Boosters such as boron.